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KMID : 0043320100330050697
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Archives of Pharmacal Research
2010 Volume.33 No. 5 p.697 ~ p.701
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Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora
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Sun Han Dong
Xiao Wei-Lie
Wang Rui Rui
Zhao Wei
Tian Ren-Rong
Shang Shan Zhai
Yang Liu Meng
Yang Jian-Hong
Pu Jian Xin
Zheng Yong Tang
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Abstract
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This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8) . The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1IIIB induced syncytium formation with EC50 values in the range of 2.26~20.4 μg/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1IIIB inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.
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KEYWORD
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Schisandra rubriflora, Lignan, NMR, CD spectrum, Anti-HIV-1 activity
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